The endocannabinoid system is fundamentally important to the regulation of digestive processes including appetite, salivation, hunger, and satiety. Cannabinoid receptors are widely distributed throughout the digestive system, as well as in the brain regions considered to be crucial to the gut-brain axis.

The endocannabinoid system is fundamentally important to the regulation of digestive processes including appetite, salivation, hunger, and satiety. Cannabinoid receptors are widely distributed throughout the digestive system, as well as in the brain regions considered to be crucial to the gut-brain axis.

Positive effects of cannabis use in the GI tract

Multiple studies have demonstrated that cannabis can be helpful in the management of Crohn’s,  IBD, IBS, and cancer-related anorexia and cachexia (appetite loss and muscle wasting). The first three conditions are even speculated to be a result of clinical endocannabinoid deficiency (CECD), a condition in which the individual does not produce enough cannabinoids or cannabinoid receptors, as...