Rewarding Companions
Oxytocin and social contact together modulate endocannabinoid activity in the mouse brain, which could help explain the prosocial effects of marijuana use.
The mammalian central nervous system is studded with receptors that bind with a small number of endogenous cannabinoids, as well as those found in marijuana. Marijuana is known to promote heightened social connection, but the mechanism for this phenomenon was not well understood. According to a paper published today (October 26) inPNAS, it is social interaction between mice plus oxytocin—the hormone involved in social bonding—that drive cannabinoid activity in the animals’ brains.
“It was a great surprise to see how powerful the effects of social contact are on production of anandamide in select regions of the brain,” said study coauthor Daniele Piomelli, a neuroscientist at the University of California, Irvine.
The brain has two known cannabinoid receptors, types 1 and 2 (CB1 and CB2). Two...
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