New Studies on Cannabis Use Yield Some Answers and More Questions

Two recent studies documenting the effects ofcannabis use on the brain did not do much for the many questions that remain about the safety and long-term implications of using marijuana.

Published in JAMA Psychiatry, the studies explored cannabis' effect on subcortical brain structure and brain maturation in adolescence in relation to risk of schizophrenia.

In the first study, David Pagliaccio, PhD, of the National Institutes of Mental Health, and colleagues analyzed the effects of cannabis use in a sample (n=483) of twins and siblings enrolled in the Human Connectome Project, 262 of which who reported using cannabis in their lifetime.

The researchers found that cannabis use was related to smaller left amygdala (approximately 2.3%; P= .007) and right ventral striatum (approximately 3.5%; P < .005) volumes, though differences were within the range of normal variation. The association between amygdala volume and cannabis use was largely owed to shared genetic factors (ρg = −0.43; P =...

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